| Date | Location | Result | |
| 02/19/22 | Wayne, NE | Sioux Falls 79, Wayne State (Neb.) 67 | Box score |
| 02/17/22 | Marshall, MN | Southwest Minn. St. 72, Wayne State (Neb.) 50 | Box score |
| 02/12/22 | Saint Paul, MN | Concordia-St. Paul 76, Wayne State (Neb.) 71 | Box score |
| 02/11/22 | Mankato, MN | Minnesota St. 95, Wayne State (Neb.) 58 | Box score |
| 02/05/22 | Wayne, NE | Wayne State (Neb.) 87, Winona St. 84 | Box score |
| 02/04/22 | Wayne, NE | Wayne State (Neb.) 74, Upper Iowa 72 | Box score |
| 01/29/22 | Bemidji, MN | Bemidji St. 60, Wayne State (Neb.) 51 | Box score |
| 01/22/22 | Wayne, NE | Minn. Duluth 69, Wayne State (Neb.) 65 | Box score |
| 01/21/22 | Wayne, NE | St. Cloud St. 72, Wayne State (Neb.) 64 | Box score |
| 01/15/22 | Minot, ND | Minot St. 71, Wayne State (Neb.) 70 | Box score |
| 01/14/22 | Bismarck, ND | Mary 72, Wayne State (Neb.) 60 | Box score |
| 01/07/22 | Wayne, NE | Northern St. 64, Wayne State (Neb.) 53 | Box score |
| 01/02/22 | Sioux Falls, SD | Augustana (SD) 74, Wayne State (Neb.) 63 | Box score |
| 12/18/21 | Fayette, IA | Wayne State (Neb.) 65, Upper Iowa 61 | Box score |
| 12/17/21 | Winona, MN | Winona St. 74, Wayne State (Neb.) 69 | Box score |
| 12/11/21 | Wayne, NE | Minnesota St. 63, Wayne State (Neb.) 52 | Box score |
| 12/10/21 | Wayne, NE | Wayne State (Neb.) 75, Concordia-St. Paul 70 | Box score |
| 12/04/21 | Sioux Falls, SD | Sioux Falls 76, Wayne State (Neb.) 75 | Box score |
| 12/02/21 | Wayne, NE | Wayne State (Neb.) 69, Southwest Minn. St. 65 (OT) | Box score |
| 11/24/21 | Wayne, NE | Wayne State (Neb.) 68, South Dakota Mines 65 (OT) | Box score |
| 11/23/21 | Wayne, NE | Wayne State (Neb.) 73, Augustana (SD) 61 | Box score |
| 11/19/21 | Wayne, NE | Black Hills St. 66, Wayne State (Neb.) 50 | Box score |
| 11/18/21 | Wayne, NE | Wayne State (Neb.) 87, Chadron St. 50 | Box score |
| 11/13/21 | Wichita, KS | Wayne State (Neb.) 72, Newman 65 | Box score |