| Date | Location | Result | |
| 02/23/22 | Wayne, NE | St. Cloud St. 100, Wayne State (Neb.) 98 (OT) | Box score |
| 02/18/22 | Wayne, NE | Wayne State (Neb.) 76, Sioux Falls 63 | Box score |
| 02/17/22 | Marshall, MN | Southwest Minn. St. 60, Wayne State (Neb.) 55 (OT) | Box score |
| 02/12/22 | Saint Paul, MN | Wayne State (Neb.) 80, Concordia-St. Paul 64 | Box score |
| 02/11/22 | Mankato, MN | Minnesota St. 81, Wayne State (Neb.) 76 | Box score |
| 02/05/22 | Wayne, NE | Wayne State (Neb.) 76, Winona St. 55 | Box score |
| 02/04/22 | Wayne, NE | Upper Iowa 79, Wayne State (Neb.) 63 | Box score |
| 01/29/22 | Bemidji, MN | Wayne State (Neb.) 77, Bemidji St. 71 | Box score |
| 01/28/22 | Crookston, MN | Minn.-Crookston 75, Wayne State (Neb.) 59 | Box score |
| 01/22/22 | Wayne, NE | Minn. Duluth 91, Wayne State (Neb.) 83 | Box score |
| 01/21/22 | Wayne, NE | Wayne State (Neb.) 83, St. Cloud St. 59 | Box score |
| 01/14/22 | Bismarck, ND | Wayne State (Neb.) 76, Mary 69 | Box score |
| 01/07/22 | Wayne, NE | Wayne State (Neb.) 69, Northern St. 53 | Box score |
| 01/02/22 | Sioux Falls, SD | Augustana (SD) 71, Wayne State (Neb.) 55 | Box score |
| 12/18/21 | Fayette, IA | Upper Iowa 88, Wayne State (Neb.) 76 | Box score |
| 12/11/21 | Wayne, NE | Wayne State (Neb.) 79, Minnesota St. 69 | Box score |
| 12/10/21 | Wayne, NE | Wayne State (Neb.) 60, Concordia-St. Paul 41 | Box score |
| 12/04/21 | Sioux Falls, SD | Sioux Falls 81, Wayne State (Neb.) 79 | Box score |
| 12/02/21 | Wayne, NE | Wayne State (Neb.) 68, Southwest Minn. St. 65 | Box score |
| 11/29/21 | Wayne, NE | Wayne State (Neb.) 67, Neb.-Kearney 64 | Box score |
| 11/27/21 | Wayne, NE | Doane 76, Wayne State (Neb.) 72 | Box score |
| 11/23/21 | Wayne, NE | Wayne State (Neb.) 63, Augustana (SD) 59 | Box score |
| 11/19/21 | Wayne, NE | Wayne State (Neb.) 95, Simpson 72 | Box score |
| 11/16/21 | Wayne, NE | Wayne State (Neb.) 74, Bellevue 40 | Box score |
| 11/13/21 | Shawnee, OK | Southeastern Okla. 80, Wayne State (Neb.) 64 | Box score |
| 11/12/21 | Shawnee, OK | Okla. Baptist 74, Wayne State (Neb.) 61 | Box score |