| Date | Location | Result | |
| Nov 13, 2021 | Moorhead, Minnesota | Wayne State (Neb.) 24, MSU Moorhead 21 | Box score |
| Nov 06, 2021 | Wayne, Nebraska | Sioux Falls 38, Wayne State (Neb.) 17 | Box score |
| Oct 30, 2021 | Fayette, Iowa | Upper Iowa 42, Wayne State (Neb.) 41 | Box score |
| Oct 23, 2021 | Marshall, Minnesota | Wayne State (Neb.) 38, Southwest Minnesota 16 | Box score |
| Oct 16, 2021 | Wayne, Nebraska | Augustana (SD) 32, Wayne State (Neb.) 24 | Box score |
| Oct 09, 2021 | Mankato, Minnesota | Wayne State (Neb.) 35, Minnesota St. 24 | |
| Oct 02, 2021 | Wayne, Nebraska | Wayne State (Neb.) 38, Winona St. 21 | Box score |
| Sep 25, 2021 | Duluth, Minnesota | Wayne State (Neb.) 31, Minn. Duluth 28 | Box score |
| Sep 18, 2021 | Wayne, Nebraska | Wayne State (Neb.) 48, Minot St. 0 | Box score |
| Sep 11, 2021 | Bemidji, Minnesota | Bemidji St. 38, Wayne State (Neb.) 28 | Box score |
| Sep 02, 2021 | Wayne, Nebraska | Wayne State (Neb.) 34, Mary 27 | Box score |