| Date | Location | Result | |
| 11/19/21 | Sioux Falls, SD | St. Cloud St. 3, Wayne State (Neb.) 2 (23-25,25-18,21-25,25-19,15-9) | Box score |
| 11/18/21 | Sioux Falls, SD | Wayne State (Neb.) 3, Northern St. 1 (25-22,25-10,20-25,25-18) | Box score |
| 11/13/21 | Wayne, Neb. | Wayne State (Neb.) 3, Minn. Duluth 0 (26-24,25-17,25-17) | Box score |
| 11/12/21 | Wayne, Neb. | St. Cloud St. 3, Wayne State (Neb.) 1 (26-24,25-16,17-25,25-18) | Box score |
| 11/06/21 | Crookston, Minn. | Wayne State (Neb.) 3, Minn.-Crookston 0 (25-15,25-13,25-12) | Box score |
| 11/05/21 | Bemidji, Minn. | Wayne State (Neb.) 3, Bemidji St. 0 (25-17,25-23,25-14) | Box score |
| 11/02/21 | Sioux Falls, S.D. | Sioux Falls 3, Wayne State (Neb.) 0 (26-24,25-19,25-22) | Box score |
| 10/30/21 | Marshall, Minn. | Southwest Minn. St. 3, Wayne State (Neb.) 1 (18-25,25-20,25-15,25-18) | Box score |
| 10/28/21 | Wayne, Neb. | Wayne State (Neb.) 3, Augustana (SD) 1 (25-16,25-18,20-25,25-17) | Box score |
| 10/23/21 | Wayne, Neb. | Winona St. 3, Wayne State (Neb.) 2 (20-25,25-21,17-25,25-16,15-13) | Box score |
| 10/22/21 | Wayne, Neb. | Wayne State (Neb.) 3, Upper Iowa 0 (25-23,30-28,25-23) | Box score |
| 10/16/21 | Mankato, MN | Wayne State (Neb.) 3, Minnesota St. 0 (25-10,25-22,25-11) | Box score |
| 10/15/21 | Saint Paul, MN | Concordia-St. Paul 3, Wayne State (Neb.) 2 (23-25,25-16,25-23,19-25,15-10) | Box score |
| 10/12/21 | Wayne, NE | Wayne State (Neb.) 3, Mt. Marty 0 (25-15,25-13,25-16) | Box score |
| 10/09/21 | Wayne, NE | Wayne State (Neb.) 3, MSU Moorhead 0 (25-8,25-20,25-12) | Box score |
| 10/08/21 | Wayne, NE | Wayne State (Neb.) 3, Northern St. 0 (25-18,25-19,25-17) | Box score |
| 10/02/21 | Minot, ND | Wayne State (Neb.) 3, Minot St. 0 (25-15,25-13,25-9) | Box score |
| 10/01/21 | Bismarck, ND | Wayne State (Neb.) 3, Mary 0 (25-14,25-11,25-17) | Box score |
| 09/25/21 | Wayne, NE | Wayne State (Neb.) 3, Bemidji St. 0 (25-14,25-12,25-11) | Box score |
| 09/24/21 | Wayne, NE | Wayne State (Neb.) 3, Minn.-Crookston 0 (25-16,25-12,25-14) | Box score |
| 09/21/21 | Wayne, NE | Wayne State (Neb.) 3, Sioux Falls 0 (25-22,25-17,25-22) | Box score |
| 09/18/21 | St. Cloud, MN | St. Cloud St. 3, Wayne State (Neb.) 1 (25-11,25-20,18-25,25-18) | Box score |
| 09/17/21 | Duluth, MN | Wayne State (Neb.) 3, Minn. Duluth 1 (28-26,25-19,19-25,25-17) | Box score |
| 09/11/21 | Denver, CO | MSU Denver 3, Wayne State (Neb.) 2 (25-16,29-31,21-25,25-17,15-12) | Box score |
| 09/11/21 | Denver, CO | Wayne State (Neb.) 3, Angelo St. 0 (25-21,25-20,25-19) | Box score |
| 09/10/21 | Denver, CO | Wayne State (Neb.) 3, Western Wash. 0 (25-22,25-17,25-22) | Box score |
| 09/10/21 | Denver, CO | Wayne State (Neb.) 3, Lewis 0 (25-20,25-14,25-23) | Box score |
| 09/04/21 | Dallas, TX | Wayne State (Neb.) 3, Eastern N.M. 0 (25-11,25-16,25-18) | Box score |
| 09/04/21 | Dallas, TX | Wayne State (Neb.) 3, Arkansas Tech 0 (25-21,25-10,25-15) | Box score |
| 09/03/21 | Dallas, TX | Wayne State (Neb.) 3, Westminster (UT) 0 (25-22,25-22,25-13) | Box score |